Sevelamer-induced Stercoral Ulceration in a Patient with End Stage Renal Disease
DOI:
https://doi.org/10.71332/7z4qvf31Keywords:
sevelamer, colonic ulceration, feculent peritonitis, end-stage renal disease, hyperphosphatemiaAbstract
This is a case describing the sequence of stercoral ulceration leading to fecal impaction and subsequent feculent peritonitis in a patient with end-stage renal disease (ESRD). Analyzing the patient’s operative course and hospitalization illustrates the complex nature of ESRD and the associated circumstances leading to this patient’s death. Utilizing the patient’s imaging and pathology results concludes that medication resins such as sevelamer caused mucosal ulceration in her colon. These results emphasize current literature which describes the potential for gastrointestinal complications with use of sevelamer.
References
Biruete, A., Hill Gallant, K. M., Lindemann, S. R., Wiese, G. N., Chen, N. X., & Moe, S. M. (2020). Phosphate binders and nonphosphate effects in the gastrointestinal tract. Journal of Renal Nutrition, 30(1), 4–10. https://doi.org/10.1053/j.jrn.2019.01.004
Madan, P., Bhayana, S., Chandra, P., & Hughes, J. I. (2008). Lower gastrointestinal bleeding: Association with sevelamer use. World Journal of Gastroenterology, 14(16), 2615–2616. https://doi.org/10.3748/wjg.14.2615
Nambiar, S., Pillai, U. K., Devasahayam, J., Oliver, T., & Karippot, A. (2018). Colonic mucosal ulceration and gastrointestinal bleeding associated with sevelamer crystal deposition in a patient with end-stage renal disease. Case Reports in Nephrology, 2018, 4708068. https://doi.org/10.1155/2018/4708068
Pant, P., LaBel, D., Hernandez Garcilazo, N., et al. (2023). Colitis associated with sevelamer carbonate: A case report. Annals of Internal Medicine Clinical Cases, 2, e220924. https://doi.org/10.7326/aimcc.2022.0924
Prlić, M. F., Jelaković, M., Brinar, M., Grgić, D., Romic, I., Marušić, Z., Ivandić, E., Jelaković, B., Vuković Brinar, I., & Krznarić, Ž. (2023). Sevelamer-associated colitis—a cause of pseudotumor formation with colon perforation and life-threatening bleeding: A case report. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1097469
Swanson, B. J., Limketkai, B. N., Liu, T. C., Montgomery, E., Nazari, K., Park, J. Y., Santangelo, W. C., Torbenson, M. S., Voltaggio, L., Yearsley, M. M., & Arnold, C. A. (2013). Sevelamer crystals in the gastrointestinal tract: A new entity associated with mucosal injury. American Journal of Surgical Pathology, 37(11), 1686–1693. https://doi.org/10.1097/PAS.0b013e3182999d8d
Todd, J., Saboori, S., Zeidan, J., Ahrens, W., Jacobs, C., & Moshiree, B. (2024). Sevelamer-induced gastrointestinal disease in 12 patients with end-stage renal disease: A case series. Clinical and Translational Gastroenterology, 15(3), e00679. https://doi.org/10.14309/ctg.0000000000000679
Yuste, C., Mérida, E., Hernández, E., García-Santiago, A., Rodríguez, Y., Muñoz, T., Gómez, G. J., Sevillano, Á., & Praga, M. (2017). Gastrointestinal complications induced by sevelamer crystals. Clinical Kidney Journal, 10(4), 539–544. https://doi.org/10.1093/ckj/sfx013
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ponce Health Sciences University Scientific Journal

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright of their articles. All works are published under the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited.